Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

WHI5 - Whi5p

Saccharomyces cerevisiae S288c

Synonyms: G1-specific transcriptional repressor WHI5, YOR083W, YOR3116W

de Bruin, R.A. et al., Costanzo, M. et al., Schaefer, J.B. et al., Cooper, K., Wittenberg, C. et al.

Cooper,

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High impact information on WHI5

Dissociation of Whi5 is promoted by Cln3 in vivo [1].
Cln/CDK phosphorylation of Whi5 in vitro promotes its dissociation from SBF complexes [1].
Whi5 associates with G1-specific promoters via SBF during early G1 phase, then dissociates coincident with transcriptional activation [1].
In this issue of Cell, two studies reveal that Whi5 appears to play the role of RB in preventing precocious cell cycle entry in budding yeast [2].
Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription [3].

Biological context of WHI5

Phosphorylation of Whi5 by Cdk1 in late G1 leads to dissociation from SBF and transcriptional derepression [4].
Here we show that the cell size regulator Whi5 inhibits G1/S transcription and that this inhibition is relieved by CDK-mediated phosphorylation [3].
Although Rb and Whi5 play similar roles in regulating G1 gene expression, they exhibit no sequence homology [5].

Other interactions of WHI5

Whi5 inactivation bypasses the requirement for Cln3 both for transcriptional activation and cell cycle initiation [1].

References

Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5. de Bruin, R.A., McDonald, W.H., Kalashnikova, T.I., Yates, J., Wittenberg, C. Cell (2004) [Pubmed]
RB from a bud's eye view. Schaefer, J.B., Breeden, L.L. Cell (2004) [Pubmed]
CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Costanzo, M., Nishikawa, J.L., Tang, X., Millman, J.S., Schub, O., Breitkreuz, K., Dewar, D., Rupes, I., Andrews, B., Tyers, M. Cell (2004) [Pubmed]
Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes. Wittenberg, C., Reed, S.I. Oncogene (2005) [Pubmed]
Rb, whi it's not just for metazoans anymore. Cooper, K. Oncogene (2006) [Pubmed]

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