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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PNO1  -  Pno1p

Saccharomyces cerevisiae S288c

Synonyms: DIM2, O3513, Partner of NOB1, Pre-rRNA-processing protein PNO1, RRP20, ...
 
 
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High impact information on PNO1

  • Overexpression of NOB1 overrode the defects in maturation of the 20S proteasome of ump1Delta cells, and temperature-sensitive nob1 and pno1 mutants exhibited defects in the processing of the beta subunits and in the assembly of the 20S and the 26S proteasomes [1].
  • Dim2p, a core constituent of the SSU RRP complex and conserved KH-domain containing protein, is required for pre-rRNA processing and is associated with early nucleolar and late cytoplasmic pre-rRNA species [2].

References

  1. Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae. Tone, Y., Toh-E, A. Genes Dev. (2002) [Pubmed]
  2. Dim2p, a KH-domain protein required for small ribosomal subunit synthesis. Vanrobays, E., Gélugne, J.P., Caizergues-Ferrer, M., Lafontaine, D.L. RNA (2004) [Pubmed]
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