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PRO2  -  glutamate-5-semialdehyde dehydrogenase

Saccharomyces cerevisiae S288c

Synonyms: GPR, GSA dehydrogenase, Gamma-glutamyl phosphate reductase, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, ...
 
 
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High impact information on PRO2

  • We found that specific mutations of PRO2, the second enzyme in proline biosynthesis, permitted the growth of Deltagsh1 in the absence of exogenous GSH [1].
  • The suppression mechanism by alleles of PRO2 involved the biosynthesis of a trace amount of glutathione [1].
  • The PRO2 gene mapped on chromosome XV tightly linked to cdc66, and the PRO3 gene was located on the right arm of chromosome V between HIS1 and the centromere [2].
  • Three complementation groups cold be defined which are believed to correspond to mutations in the three genes (pro1, pro2, and pro3) coding for the three enzymes of the pathway [3].
  • Of the two polyproline stretches, only one (Pro2) is required for binding specificity to both endophilin 1 and endophilin 3 [4].
 

Associations of PRO2 with chemical compounds

References

  1. A genetic investigation of the essential role of glutathione: mutations in the proline biosynthesis pathway are the only suppressors of glutathione auxotrophy in yeast. Spector, D., Labarre, J., Toledano, M.B. J. Biol. Chem. (2001) [Pubmed]
  2. Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae. Tomenchok, D.M., Brandriss, M.C. J. Bacteriol. (1987) [Pubmed]
  3. Isolation and preliminary characterization of Saccharomyces cerevisiae proline auxotrophs. Brandriss, M.C. J. Bacteriol. (1979) [Pubmed]
  4. Identification of Endophilins 1 and 3 as Selective Binding Partners for VGLUT1 and Their Co-Localization in Neocortical Glutamatergic Synapses: Implications for Vesicular Glutamate Transporter Trafficking and Excitatory Vesicle Formation. De Gois, S., Jeanclos, E., Morris, M., Grewal, S., Varoqui, H., Erickson, J.D. Cell. Mol. Neurobiol. (2006) [Pubmed]
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