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Gene Review

GPP1  -  glycerol-1-phosphatase RHR2

Saccharomyces cerevisiae S288c

Synonyms: (DL)-glycerol-3-phosphatase 1, Glycerol-1-phosphate phosphohydrolase 1, RHR2, Related to HOR2 protein 2, YIL053W
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High impact information on RHR2

  • Transfer to anaerobic conditions does not affect expression of GPP2, whereas GPP1 is transiently induced, and mutants lacking GPP1 show poor anaerobic growth [1].
  • Previous studies have shown that expression of both GPP1 and GPP2 is induced under hyperosmotic stress and that induction partially depends on the HOG (high osmolarity glycerol) pathway [1].
  • However, cells overexpressing YIG1 exhibited only slightly decreased GPP1 transcript levels, suggesting that Yig1p modulates expression on both transcriptional and post-transcriptional levels [2].
  • At high demand for NADH reoxidation, a strong induction was seen not only of the GPD2 gene, but also of GPP1, encoding one of the molecular forms of glycerol-3-phosphatase [3].

Biological context of RHR2

  • Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway [4].

Associations of RHR2 with chemical compounds

  • In contrast, overexpression of GPP1, encoding glycerol 3-phosphatase (Gpp1p), did not enhance glycerol production [5].


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