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CKA1  -  casein kinase 2 catalytic subunit CKA1

Saccharomyces cerevisiae S288c

Synonyms: CK II subunit alpha, Casein kinase II subunit alpha, YIL035C
 
 
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High impact information on CKA1

  • Moreover, Ypi1, a Glc7-specific inhibitor, or the Cka1 kinase blocks poly(A) addition in wild-type (wt) extract [1].
  • The alpha' subunit encoded by the CKA2 gene is 60% identical to the CKA1-encoded alpha subunit and 55% identical to the Drosophila alpha subunit (A. Saxena, R. Padmanabha, and C. V. C. Glover, Mol. Cell. Biol. 7:3409-3417, 1987) [2].
  • Casein kinase II of Saccharomyces cerevisiae contains two distinct catalytic subunits, alpha and alpha', which are encoded by the CKA1 and CKA2 genes, respectively [2].
  • Null mutations in the CKA1 gene do not confer a detectable phenotype (J. L.-P. Chen-Wu, R. Padmanabha, and C. V. C. Glover, Mol. Cell. Biol. 8:4981-4990, 1988), presumably because of the presence of the CKA2 gene [2].
  • The CKA1 gene product appears to be distantly related to other known protein kinases but exhibits highest similarity to the CDC28 gene product and its homolog in other species [3].
 

Biological context of CKA1

  • Casein kinase II (CKII) of Saccharomyces cerevisiae contains two distinct catalytic subunits, alpha and alpha', that are encoded by the CKA1 and -2 genes, respectively [4].
  • Temperature-sensitive mutations of the CKA1 gene reveal a role for casein kinase II in maintenance of cell polarity in Saccharomyces cerevisiae [4].
  • Interestingly, the CKA1 gene appears to be single copy in the yeast genome; i.e., the alpha' gene, whose existence is known from biochemical studies and protein sequencing, cannot be detected by low-stringency hybridization [3].
  • This gene (designated CKA1) contains an intron-free open reading frame of 372 amino acid residues [3].
  • Haploid and diploid strains lacking a functional CKA1 gene appear to be phenotypically wild type, presumably because of the presence of the alpha' gene [3].
 

Other interactions of CKA1

References

  1. Regulation of yeast mRNA 3' end processing by phosphorylation. He, X., Moore, C. Mol. Cell (2005) [Pubmed]
  2. Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae. Padmanabha, R., Chen-Wu, J.L., Hanna, D.E., Glover, C.V. Mol. Cell. Biol. (1990) [Pubmed]
  3. Isolation, sequencing, and disruption of the CKA1 gene encoding the alpha subunit of yeast casein kinase II. Chen-Wu, J.L., Padmanabha, R., Glover, C.V. Mol. Cell. Biol. (1988) [Pubmed]
  4. Temperature-sensitive mutations of the CKA1 gene reveal a role for casein kinase II in maintenance of cell polarity in Saccharomyces cerevisiae. Rethinaswamy, A., Birnbaum, M.J., Glover, C.V. J. Biol. Chem. (1998) [Pubmed]
  5. Purification and characterization of casein kinase II (CKII) from delta cka1 delta cka2 Saccharomyces cerevisiae rescued by Drosophila CKII subunits. The free catalytic subunit of casein kinase II is not toxic in vivo. Bidwai, A.P., Hanna, D.E., Glover, C.V. J. Biol. Chem. (1992) [Pubmed]
  6. A specific catalytic subunit isoform of protein kinase CK2 is required for phosphorylation of the repressor Nrg1 in Saccharomyces cerevisiae. Berkey, C.D., Carlson, M. Curr. Genet. (2006) [Pubmed]
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