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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IMD4  -  IMP dehydrogenase IMD4

Saccharomyces cerevisiae S288c

Synonyms: IMP dehydrogenase 4, IMPD 4, IMPDH 4, Inosine-5'-monophosphate dehydrogenase 4, YM9958.06C, ...
 
 
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High impact information on IMD4

  • The yeast IMD2 to IMD4 and GUA1 genes, involved in GMP synthesis, are highly expressed in exponentially growing cells but are shut off when cells cease to grow upon nutrient limitation [1].
  • To understand the molecular basis of this drug-sensitive phenotype, we have dissected the expression and function of a four-gene family in yeast called IMD1 through IMD4 [2].
 

Other interactions of IMD4

  • When overexpressed, IMD3 or IMD4 weakly compensated for deletion of IMD2 [2].

References

  1. Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Escobar-Henriques, M., Collart, M.A., Daignan-Fornier, B. Mol. Cell. Biol. (2003) [Pubmed]
  2. Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. Hyle, J.W., Shaw, R.J., Reines, D. J. Biol. Chem. (2003) [Pubmed]
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