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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CAT2  -  carnitine O-acetyltransferase CAT2

Saccharomyces cerevisiae S288c

Synonyms: CAT, Carnitine O-acetyltransferase, mitochondrial, Carnitine acetylase, YCAT, YM8054.01, ...
 
 
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High impact information on CAT2

  • The lack of phenotype of the cit2 mutant indicated the presence of an alternative pathway for transport of acetyl units, formed by the carnitine acetyltransferase protein (YCAT) [1].
  • Determination of the 5'-ends of YCAT mRNAs revealed that YCAT transcripts initiating after the first AUG were present in oleate-grown cells [2].
  • CAT2 is localized to the tonoplast in transformed Arabidopsis protoplasts and thus may encode the long-sought vacuolar amino acid transporter [3].
  • After alleviation of carbon catabolite repression, gene CAT1 becomes active and prevents the activity of CAT2 which functions as a repressor of sensitive enzyme synthesis [4].
 

Associations of CAT2 with chemical compounds

  • The CAT2 activity represented a minor fraction of the catalase activity in spores and H(2)O(2)-stressed mycelium, and no phenotype was observed for Cat2-deleted strains, which showed a normal response to H(2)O(2) treatment [5].

References

  1. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. van Roermund, C.W., Elgersma, Y., Singh, N., Wanders, R.J., Tabak, H.F. EMBO J. (1995) [Pubmed]
  2. Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene. Elgersma, Y., van Roermund, C.W., Wanders, R.J., Tabak, H.F. EMBO J. (1995) [Pubmed]
  3. Molecular and functional characterization of a family of amino acid transporters from Arabidopsis. Su, Y.H., Frommer, W.B., Ludewig, U. Plant Physiol. (2004) [Pubmed]
  4. Genetics of carbon catabolite repression in Saccharomycess cerevisiae: genes involved in the derepression process. Zimmermann, F.K., Kaufmann, I., Rasenberger, H., Haubetamann, P. Mol. Gen. Genet. (1977) [Pubmed]
  5. Identification of two highly divergent catalase genes in the fungal tomato pathogen, Cladosporium fulvum. Bussink, H.J., Oliver, R. Eur. J. Biochem. (2001) [Pubmed]
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