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Gene Review

OST6  -  Ost6p

Saccharomyces cerevisiae S288c

Synonyms: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6, OTase 37 kDa subunit, Oligosaccharyl transferase 37 kDa subunit, Oligosaccharyl transferase subunit OST6, YML019W
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High impact information on OST6

  • In the case of Ost5p and Ost6p, both their N and C termini are present in the cytosol [1].
  • These findings also suggested that Ost2p, Stt3p, Ost5p, and Ost6p do not have a cleavable N-terminal signal sequence [1].
  • Interestingly, Ost3p and Ost6p subunits exhibited a surprisingly identical pattern of cross-linking to other subunits, which is consistent with their proposed redundant function [2].
  • The OST6-complex was found to be important for cell wall integrity and temperature stress [3].
  • By blue native polyacrylamide electrophoresis we show that yeast OST consists of two isoforms with distinct functions differing only in the presence of the two related Ost3 and Ost6p proteins [3].

Biological context of OST6

  • Disruption of OST6 or OST3 causes only a minor defect in N-glycosylation, but an Deltaost3Deltaost6 double mutant displays a synthetic phenotype, leading to a severe underglycosylation of soluble and membrane-bound glycoproteins in vivo and to a reduced OST activity in vitro [4].

Other interactions of OST6

  • In this study we report the identification and functional characterization of a new OST gene, designated OST6, that has homology to OST3 and in particular a strikingly similar membrane topology [4].
  • We demonstrate that the small 3.4-kDa subunit Ost4p is required for the incorporation of either Ost3p or Ost6p into the complex, resulting in two, functionally distinct OTase complexes in vivo [5].


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