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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TAF4  -  Taf4p

Saccharomyces cerevisiae S288c

Synonyms: MPT-1, MPT1, TAF suppressor gene 2 protein, TAF48, TAFII-48, ...
 
 
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High impact information on TAF4

  • Site-specific photocross-linkers and tethered protein cleavage reagents positioned on the NTD of TFIIA and assembled in PICs identified the SAGA subunit Spt8 and the TFIID subunit Taf4 as located near this surface [1].
  • Region 4 of Taf1p is mutationally sensitive, can assemble several Tafps into a partial TFIID complex, and interacts directly with Taf4p and Taf6p [2].
  • This phenotype remarkably resembles the previously described effects of similarly depleting two C. elegans histone fold TAF(II)s, TAF-9 (hTAF(II)31/32) and TAF-10 (hTAF(II)30), but is distinct from the widespread transcription block caused by TAF-4 (hTAF(II)130) depletion [3].
  • We have identified a high copy suppressor of the TAF68/61 mutation, TSG2, that has sequence similarity to a region of the SAGA subunit Ada1 [4].
  • On the basis of these functions, we propose that Tsg2/TAF(II)48p is the histone 2A-like dimerization partner for the histone 2B-like TAF(II)68/61p in the yeast TFIID complex [4].
 

Biological context of TAF4

References

  1. Positive and negative functions of the SAGA complex mediated through interaction of Spt8 with TBP and the N-terminal domain of TFIIA. Warfield, L., Ranish, J.A., Hahn, S. Genes Dev. (2004) [Pubmed]
  2. Molecular and genetic characterization of a Taf1p domain essential for yeast TFIID assembly. Singh, M.V., Bland, C.E., Weil, P.A. Mol. Cell. Biol. (2004) [Pubmed]
  3. A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans. Walker, A.K., Blackwell, T.K. J. Biol. Chem. (2003) [Pubmed]
  4. Identification of a yeast transcription factor IID subunit, TSG2/TAF48. Reese, J.C., Zhang, Z., Kurpad, H. J. Biol. Chem. (2000) [Pubmed]
  5. Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex. Sanders, S.L., Weil, P.A. J. Biol. Chem. (2000) [Pubmed]
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