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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ADI1  -  acireductone dioxygenase (Ni2+-requiring)

Saccharomyces cerevisiae S288c

Synonyms: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, ARD, Acireductone dioxygenase (Fe(2+)-requiring), Fe-ARD, YM8270.12, ...
 
 
 
 
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High impact information on ADI1

  • We propose that Rnt1p cleavage targets degradation of the ADI1 mRNA to prevent its expression prior to heat shock conditions and that RNA surveillance by multiple ribonucleases helps prevent accumulation of aberrant 3'-extended forms of this mRNA that arise from intrinsically inefficient 3'-processing signals [1].
  • Cleavage occurs in a large bipartite stem loop structure present in the open reading frame region of the ADI1 mRNA [1].
 

Regulatory relationships of ADI1

  • We show that the ADI1 mRNA is up-regulated under heat shock conditions in a Rnt1p-independent manner [1].

References

  1. Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation. Zer, C., Chanfreau, G. J. Biol. Chem. (2005) [Pubmed]
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