High impact information on ERB1

• The identification of several new nucleolar proteins without an obvious role in pre-rRNA metabolism may provide the field with long sought after assembly factors that might be key players in eukaryotic ribosome biogenesis [1].
• The split operon system should facilitate future efforts to dissect eukaryotic ribosome biogenesis [2].
• Mutations in the WD40 motifs of Ytm1 disrupt binding to Erb1, destabilize the heterotrimer, and delay pre-rRNA processing and nuclear export of preribosomes [3].
• However, Nop7 and Erb1 assemble into preribosomes prior to Ytm1 [3].

Anatomical context of ERB1

• Eukaryotic ribosome biogenesis requires multiple steps of nuclear transport because ribosomes are assembled in the nucleus while protein synthesis occurs in the cytoplasm [4].

Other interactions of ERB1

• Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes [3].
• The small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) are crucial trans-acting factors intervening in eukaryotic ribosome biogenesis [5].

References