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Gene Review

FAR3  -  Far3p

Saccharomyces cerevisiae S288c

Synonyms: Factor arrest protein 3, YM9796.05, YMR052W
 
 
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High impact information on FAR3

  • Moreover, velocity sedimentation experiments suggest that Far3 and Far7 to Far11 form a complex [1].
  • Only a handful of genes required for the interface between pheromone response and the cell cycle have been identified, among them FAR1 and FAR3; of these, only FAR1 has been extensively characterized [1].
  • However, mutations in two loci, one inactivating FAR3 and one upstream of CYR1, identified in evolving populations, were shown to have small but significantly positive fitness effects [2].
  • Northern blot experiments indicated that FAR3 expression is constitutive with respect to cell type, pheromone treatment, and cell cycle position [3].
  • I have used strains harboring the far3-1 mutation to map the gene to the right arm of chromosome XIII, establishing the gene order CEN13-LYS7-MCM1-FAR3 [4].
 

Biological context of FAR3

 

Other interactions of FAR3

  • We conclude that the FAR3-dependent arrest pathway is functionally distinct from that which employs FAR1 [1].
 

Analytical, diagnostic and therapeutic context of FAR3

  • In an effort to learn about the mechanism by which Far3 acts, we used the two-hybrid method to identify interacting proteins [1].

References

 
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