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TIF34  -  translation initiation factor eIF3 subunit i

Saccharomyces cerevisiae S288c

Synonyms: Eukaryotic translation initiation factor 3 39 kDa subunit, Eukaryotic translation initiation factor 3 subunit I, YM9375.16C, YMR146C, eIF-3 39 kDa subunit, ...
 
 
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High impact information on TIF34

  • Our results provide support for both physical and functional interactions between three subunits, TIF34, PRT1 and p33, in the eIF3 complex [1].
  • Using temperature-sensitive mutants of TIF34 we show that this protein is required for cell cycle progression and for mating and plays an essential role in initiation of protein synthesis [1].
  • Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation [1].
  • As eIF3-p39 levels fall, polysomes become smaller, indicating a role for eIF3-p39 in the initiation phase of protein synthesis [2].
  • Taken together, the results indicate that eIF3-p39 plays an important, although not necessarily direct, role in the initiation phase of protein synthesis and suggest that it may be required for the assembly and maintenance of the eIF3 complex in eukaryotic cells [2].
 

Physical interactions of TIF34

  • Discrete segments (70-150 amino acids) of PRT1 and TIF35 were found to be responsible for their binding to TIF34 [3].

References

  1. Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation. Verlhac, M.H., Chen, R.H., Hanachi, P., Hershey, J.W., Derynck, R. EMBO J. (1997) [Pubmed]
  2. The 39-kilodalton subunit of eukaryotic translation initiation factor 3 is essential for the complex's integrity and for cell viability in Saccharomyces cerevisiae. Naranda, T., Kainuma, M., MacMillan, S.E., Hershey, J.W. Mol. Cell. Biol. (1997) [Pubmed]
  3. Complex formation by all five homologues of mammalian translation initiation factor 3 subunits from yeast Saccharomyces cerevisiae. Asano, K., Phan, L., Anderson, J., Hinnebusch, A.G. J. Biol. Chem. (1998) [Pubmed]
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