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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FAA4  -  long-chain fatty acid-CoA ligase FAA4

Saccharomyces cerevisiae S288c

Synonyms: Fatty acid activator 4, Long-chain acyl-CoA synthetase 4, Long-chain-fatty-acid--CoA ligase 4, YM9408.08, YMR246W
 
 
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High impact information on FAA4

  • Multicopy FAA4 could not suppress the growth defect in the faa1Delta fat1Delta strain indicating some essential functions of Fat1p cannot be performed by Faa4p [1].
  • The Acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular Utilization [2].
  • Although substitution of nmt1-451D for NMT1 results in deficiencies in protein N-myristoylation, these deficiencies are modest and limited by compensatory responses that include augmented expression of nmt1-451D and precocious induction of FAA4 in log phase [3].
 

Other interactions of FAA4

  • Simultaneous disruption of FAA1 and FAA4, which encode long chain (C14-C18) fatty acyl-CoA synthetases, effectively blocks the import of long chain saturated and unsaturated fatty acids [4].

References

  1. Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex. Zou, Z., Tong, F., Faergeman, N.J., Børsting, C., Black, P.N., DiRusso, C.C. J. Biol. Chem. (2003) [Pubmed]
  2. The Acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular Utilization. Faergeman, N.J., Black, P.N., Zhao, X.D., Knudsen, J., DiRusso, C.C. J. Biol. Chem. (2001) [Pubmed]
  3. A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase. Ashrafi, K., Farazi, T.A., Gordon, J.I. J. Biol. Chem. (1998) [Pubmed]
  4. The Saccharomyces cerevisiae FAT1 gene encodes an acyl-CoA synthetase that is required for maintenance of very long chain fatty acid levels. Choi, J.Y., Martin, C.E. J. Biol. Chem. (1999) [Pubmed]
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