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Gene Review

SCW10  -  Scw10p

Saccharomyces cerevisiae S288c

Synonyms: Soluble cell wall protein 10, YM9952.07C, YMR305C
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High impact information on SCW10

  • The identified proteins include 12 predicted glycosylphosphatidylinositol-modified CWPs, all four members of the Pir protein family, and three additional proteins (Scw4p, Scw10p, and Tos1p) that are, like Pir proteins, connected to the cell wall glycan network via an alkali-sensitive linkage [1].
  • The double knockout of SCW4 and the homologous gene SCW10 resulted in slower growth, significantly increased release of proteins from intact cells by DTT, and highly decreased mating efficiency when these two genes were disrupted in both mating types [2].
  • The synergistic behavior of the disruption of SCW4 and SCW10 was partly antagonized by the disruption of BGL2 [2].
  • Simultaneous deletion of SCW4 and SCW10 showed a synergistic effect, and activated the cell-wall compensatory mechanism in a PKC1-dependent manner [3].
  • Scw10p, a cell-wall glucanase/transglucosidase important for cell-wall stability in Saccharomyces cerevisiae [3].

Biological context of SCW10


Associations of SCW10 with chemical compounds

  • It was found that the lack of the non-covalently bound wall proteins Scw4p, Scw10p and Bgl2p increases the mortality of Saccharomyces cerevisiae cells grown exponentially under standard laboratory conditions, as assayed by methylene blue staining [4].

Other interactions of SCW10

  • The data suggest that Scw4p and Scw10p act as glucanases or transglucosidases in concert with other cell-wall proteins to assure cell-wall integrity [3].
  • In addition, the synthetic interactions between Bgl2p and Scw10p which support a functional cooperation in cell-wall assembly were analysed [3].


  1. Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages. Yin, Q.Y., de Groot, P.W., Dekker, H.L., de Jong, L., Klis, F.M., de Koster, C.G. J. Biol. Chem. (2005) [Pubmed]
  2. New potential cell wall glucanases of Saccharomyces cerevisiae and their involvement in mating. Cappellaro, C., Mrsa, V., Tanner, W. J. Bacteriol. (1998) [Pubmed]
  3. Scw10p, a cell-wall glucanase/transglucosidase important for cell-wall stability in Saccharomyces cerevisiae. Sestak, S., Hagen, I., Tanner, W., Strahl, S. Microbiology (Reading, Engl.) (2004) [Pubmed]
  4. Increased mortality of Saccharomyces cerevisiae cell wall protein mutants. Teparić, R., Stuparević, I., Mrsa, V. Microbiology (Reading, Engl.) (2004) [Pubmed]
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