The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

ELP6  -  Elongator subunit ELP6

Saccharomyces cerevisiae S288c

Synonyms: Elongator complex protein 6, Gamma-toxin target 6, HAP3, HAT-associated protein 3, KTI4, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of ELP6

  • Deletions of both TOT6 and TOT7 result in the complex tot phenotype, including resistance to zymocin, thermosensitivity, slow growth and hypersensitivity towards drugs, thus reinforcing the notion that TOT/Elongator may be crucial in signalling zymocicity [1].
 

High impact information on ELP6

  • The Saccharomyces cerevisiae Elongator complex consisting of the six Elp1-Elp6 proteins has been proposed to participate in three distinct cellular processes: transcriptional elongation, polarized exocytosis, and formation of modified wobble uridines in tRNA [2].
  • Disruption of the two nonessential new Elongator-encoding genes, ELP4 and ELP6, caused the same phenotypes observed with knockouts of the original Elongator-encoding genes [3].
  • Deletions of genes for two Hap subunits, HAP1 and HAP3, confer pGKL killer-insensitive and weak Elongator phenotypes [4].
  • Optimal expression of these three genes also requires Hap3p and Hap4p and is regulated by carbon source [5].

References

  1. Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator. Jablonowski, D., Frohloff, F., Fichtner, L., Stark, M.J., Schaffrath, R. Mol. Microbiol. (2001) [Pubmed]
  2. Elevated Levels of Two tRNA Species Bypass the Requirement for Elongator Complex in Transcription and Exocytosis. Esberg, A., Huang, B., Johansson, M.J., Bystr??m, A.S. Mol. Cell (2006) [Pubmed]
  3. Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae. Krogan, N.J., Greenblatt, J.F. Mol. Cell. Biol. (2001) [Pubmed]
  4. A multiprotein complex that interacts with RNA polymerase II elongator. Li, Y., Takagi, Y., Jiang, Y., Tokunaga, M., Erdjument-Bromage, H., Tempst, P., Kornberg, R.D. J. Biol. Chem. (2001) [Pubmed]
  5. A genetic screen to isolate genes regulated by the yeast CCAAT-box binding protein Hap2p. Dang, V.D., Valens, M., Bolotin-Fukuhara, M., Daignan-Fornier, B. Yeast (1994) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities