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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SPS19  -  Sps19p

Saccharomyces cerevisiae S288c

Synonyms: N1362, Peroxisomal 2,4-dienoyl-CoA reductase SPS19, SPX19, Sporulation-specific protein SPX19, YNL202W
 
 
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High impact information on SPS19

  • Propagation of yeast cells on trans-9 elaidic acid medium resulted in transcriptional up-regulation of the SPS19 gene, whose promoter contains an oleate response element [1].
  • SPS19 is dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate [2].
  • SPS19 shares with the sporulation-specific SPS18 a common promoter region that contains an oleate response element [2].
  • The SPS19 ORE is the binding target of the Pip2p and Oaf1p transcription factors, and an SPS19-lacZ reporter gene, which is highly expressed in oleate-induced cells, is not activated in haploids devoid of either protein [3].
  • We examined the expression of CYC1-lacZ reporter constructs carrying the SPS19 and CTA1 OREs in diploids propagated under sporulation conditions and have shown that OREs are not sufficient for heterologous expression during yeast development [3].
 

Biological context of SPS19

 

Associations of SPS19 with chemical compounds

  • Together with an additional segment that overlaps a portion of the canonical ORE, this region forms a continuous element (termed UAS(SPS19)) that is essential for de-repression of SPS19 when glucose levels are low [5].
 

Regulatory relationships of SPS19

  • These genes are divergently controlled by the same promoter but with SPS18 expressed at four times the level of SPS19 [8].
 

Other interactions of SPS19

  • Two novel sporulation-specific genes, SPS18 and SPS19, were isolated using this technique [8].
  • Genes coding for Dur1.2p, Dal2p, and Sps19p were down-regulated [9].
 

Analytical, diagnostic and therapeutic context of SPS19

  • RT-PCR showed that the expression of the SPS19 homolog was highest in conjugation-promoted cells but low in vegetative cells [7].

References

  1. Peroxisomal degradation of trans-unsaturated fatty acids in the yeast Saccharomyces cerevisiae. Gurvitz, A., Hamilton, B., Ruis, H., Hartig, A. J. Biol. Chem. (2001) [Pubmed]
  2. The Saccharomyces cerevisiae peroxisomal 2,4-dienoyl-CoA reductase is encoded by the oleate-inducible gene SPS19. Gurvitz, A., Rottensteiner, H., Kilpeläinen, S.H., Hartig, A., Hiltunen, J.K., Binder, M., Dawes, I.W., Hamilton, B. J. Biol. Chem. (1997) [Pubmed]
  3. Regulation of the yeast SPS19 gene encoding peroxisomal 2,4-dienoyl-CoA reductase by the transcription factors Pip2p and Oaf1p: beta-oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium. Gurvitz, A., Rottensteiner, H., Hiltunen, J.K., Binder, M., Dawes, I.W., Ruis, H., Hamilton, B. Mol. Microbiol. (1997) [Pubmed]
  4. Adr1p-dependent regulation of the oleic acid-inducible yeast gene SPS19 encoding the peroxisomal beta-oxidation auxiliary enzyme 2,4-dienoyl-CoA reductase. Gurvitz, A., Wabnegger, L., Rottensteiner, H., Dawes, I.W., Hartig, A., Ruis, H., Hamilton, B. Mol. Cell Biol. Res. Commun. (2000) [Pubmed]
  5. A novel element in the promoter of the Saccharomyces cerevisiae gene SPS19 enhances ORE-dependent up-regulation in oleic acid and is essential for de-repression. Gurvitz, A., Hamilton, B., Hartig, A., Ruis, H., Dawes, I.W., Rottensteiner, H. Mol. Gen. Genet. (1999) [Pubmed]
  6. Mapping of the divergently transcribed sporulation-specific genes SPS18 and SPS19 to the left arm of chromosome XIV of Saccharomyces cerevisiae. Coe, J.G., Hamberg, K., Dawes, I.W. Yeast (1994) [Pubmed]
  7. Identification of a gene induced in conjugation-promoted cells of toxic marine dinoflagellates Alexandrium tamarense and Alexandrium catenella using differential display analysis. Hosoi-Tanabe, S., Tomishima, S., Nagai, S., Sako, Y. FEMS Microbiol. Lett. (2005) [Pubmed]
  8. Identification of a sporulation-specific promoter regulating divergent transcription of two novel sporulation genes in Saccharomyces cerevisiae. Coe, J.G., Murray, L.E., Dawes, I.W. Mol. Gen. Genet. (1994) [Pubmed]
  9. Gene regulation in response to overexpression of cytochrome P450 and proliferation of the endoplasmic reticulum in Saccharomyces cerevisiae. Zimmer, T., Ogura, A., Takewaka, T., Zimmer, R.M., Ohta, A., Takagi, M. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
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