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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SAM50  -  Sam50p

Saccharomyces cerevisiae S288c

Synonyms: N2802, OMP85, Sorting assembly machinery 50 kDa subunit, TOB complex 55 kDa subunit, TOB55, ...
 
 
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High impact information on SAM50

  • The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria [1].
  • The mitochondrial outer membrane contains two integral proteins essential for cell viability, Tom40 of the translocase of the outer membrane (TOM complex) and Sam50 of the sorting and assembly machinery (SAM complex) [2].
  • The presence of two essential proteins in the SAM complex, Sam35 and Sam50, indicates that it plays a central role in mitochondrial biogenesis [2].
  • An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane [3].
  • Known constituents of this complex are Tob55 and Mas37 [4].
 

Other interactions of SAM50

References

  1. The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria. Gentle, I., Gabriel, K., Beech, P., Waller, R., Lithgow, T. J. Cell Biol. (2004) [Pubmed]
  2. Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. Milenkovic, D., Kozjak, V., Wiedemann, N., Lohaus, C., Meyer, H.E., Guiard, B., Pfanner, N., Meisinger, C. J. Biol. Chem. (2004) [Pubmed]
  3. An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. Kozjak, V., Wiedemann, N., Milenkovic, D., Lohaus, C., Meyer, H.E., Guiard, B., Meisinger, C., Pfanner, N. J. Biol. Chem. (2003) [Pubmed]
  4. Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. Waizenegger, T., Habib, S.J., Lech, M., Mokranjac, D., Paschen, S.A., Hell, K., Neupert, W., Rapaport, D. EMBO Rep. (2004) [Pubmed]
  5. The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Meisinger, C., Rissler, M., Chacinska, A., Szklarz, L.K., Milenkovic, D., Kozjak, V., Schönfisch, B., Lohaus, C., Meyer, H.E., Yaffe, M.P., Guiard, B., Wiedemann, N., Pfanner, N. Dev. Cell (2004) [Pubmed]
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