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Gene Review

HEF3  -  translation elongation factor EF-3

Saccharomyces cerevisiae S288c

Synonyms: EF-3B, Elongation factor 3B, Homolog of EF-3, N2846, Translation elongation factor 3B, ...
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High impact information on HEF3

  • All but YEF3B were shown through reporter gene assays to be controlled by a master regulator of zinc homeostasis now known to be encoded by ZAP1 [1].
  • Ribosome-dependent ATPase activity of EF-3A was more efficient than EF-3B, since the Kcat and Kcat/K(m) values for EF-3A were about two-fold higher; however, the difference in Kcat/K(m) values between the two factors was small for basal ATPase activity [2].

Biological context of HEF3

  • A paralog (intraspecies homolog) of the Saccharomyces cerevisiae YEF3 gene, encoding elongation factor-3, has been sequenced in the course of the yeast genome project, and identified by database searching; this gene has been designated HEF3 [3].

Other interactions of HEF3

  • YEF3B is not expressed during growth under laboratory conditions, and thus cannot rescue growth of YEF3A deletion strains [2].

Analytical, diagnostic and therapeutic context of HEF3

  • Bioinformatic and Northern blot analysis indicate that the HEF3 gene is not expressed during vegetative growth [3].


  1. Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Yuan, D.S. Genetics (2000) [Pubmed]
  2. Identification and kinetic analysis of a functional homolog of elongation factor 3, YEF3 in Saccharomyces cerevisiae. Sarthy, A.V., McGonigal, T., Capobianco, J.O., Schmidt, M., Green, S.R., Moehle, C.M., Goldman, R.C. Yeast (1998) [Pubmed]
  3. A highly conserved intraspecies homolog of the Saccharomyces cerevisiae elongation factor-3 encoded by the HEF3 gene. Maurice, T.C., Mazzucco, C.E., Ramanathan, C.S., Ryan, B.M., Warr, G.A., Puziss, J.W. Yeast (1998) [Pubmed]
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