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Gene Review

SPO1  -  Spo1p

Saccharomyces cerevisiae S288c

Synonyms: N2858, Sporulation-specific protein 1, YNL012W
 
 
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High impact information on SPO1

  • The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes catalyze a two-step reaction leading to a soluble LL-dityrosine-containing precursor of the yeast spore wall [1].
  • Dityrosine is a sporulation-specific component of the yeast ascospore wall that is essential for the resistance of the spores to adverse environmental conditions [1].
  • Thus, in wild-type strains, the increased expression of IME1 in starved a/alpha cells can account entirely for cell type control, but only partially for nutritional control, of early sporulation-specific gene expression [2].
  • A second sporulation-specific gene, designated SPO16, was found adjacent to SPO12 and shown to be necessary for efficient spore formation [3].
  • We found that the introduction into a yeast cell of a high-copy-number plasmid containing the 5' end of the SPS2 gene, a sporulation-specific gene of Saccharomyces cerevisiae, led to a reduction in the efficiency of spore formation [4].
 

Biological context of SPO1

  • The phenotype of a complete deletion indicates that SPO1 is dispensable for vegetative growth, premeiotic DNA synthesis and meiotic recombination [5].
  • At present SPO1 is the only known gene required for SPB duplication in meiosis but not in mitosis [5].
  • Alteration of a conserved serine residue in the putative phospholipase active site, and presence of the spo1-1 temperature-sensitive mutation, which resides near this site, each result in loss of SPO1 function [5].
  • The SPO1 gene product required for meiosis in yeast has a high similarity to phospholipase B enzymes [6].
  • ORF N2016 is immediately adjacent to the centromere, suggesting that it corresponds to the SPO1 gene, which is very tightly linked to the centromere at the left arm side of chromosome XIV (Mortimer et al., 1989) [7].
 

Anatomical context of SPO1

 

Associations of SPO1 with chemical compounds

 

Other interactions of SPO1

 

Analytical, diagnostic and therapeutic context of SPO1

References

  1. The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes catalyze a two-step reaction leading to a soluble LL-dityrosine-containing precursor of the yeast spore wall. Briza, P., Eckerstorfer, M., Breitenbach, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae. Smith, H.E., Su, S.S., Neigeborn, L., Driscoll, S.E., Mitchell, A.P. Mol. Cell. Biol. (1990) [Pubmed]
  3. Complementary transcripts from two genes necessary for normal meiosis in the yeast Saccharomyces cerevisiae. Malavasic, M.J., Elder, R.T. Mol. Cell. Biol. (1990) [Pubmed]
  4. Increased copy number of the 5' end of the SPS2 gene inhibits sporulation of Saccharomyces cerevisiae. Percival-Smith, A., Segall, J. Mol. Cell. Biol. (1987) [Pubmed]
  5. Spo1, a phospholipase B homolog, is required for spindle pole body duplication during meiosis in Saccharomyces cerevisiae. Tevzadze, G.G., Swift, H., Esposito, R.E. Chromosoma (2000) [Pubmed]
  6. The SPO1 gene product required for meiosis in yeast has a high similarity to phospholipase B enzymes. Tevzadze, G.G., Mushegian, A.R., Esposito, R.E. Gene (1996) [Pubmed]
  7. Nucleotide sequence analysis of an 8887 bp region of the left arm of yeast chromosome XIV, encompassing the centromere sequence. Verhasselt, P., Aert, R., Voet, M., Volckaert, G. Yeast (1994) [Pubmed]
  8. Genetic Evidence for a SPO1-Dependent Signaling Pathway Controlling Meiotic Progression in Yeast. Tevzadze, G.G., Pierce, J.V., Esposito, R.E. Genetics (2007) [Pubmed]
  9. The SPS4 gene of Saccharomyces cerevisiae encodes a major sporulation-specific mRNA. Garber, A.T., Segall, J. Mol. Cell. Biol. (1986) [Pubmed]
  10. The Saccharomyces cerevisiae peroxisomal 2,4-dienoyl-CoA reductase is encoded by the oleate-inducible gene SPS19. Gurvitz, A., Rottensteiner, H., Kilpeläinen, S.H., Hartig, A., Hiltunen, J.K., Binder, M., Dawes, I.W., Hamilton, B. J. Biol. Chem. (1997) [Pubmed]
  11. Spe3, which encodes spermidine synthase, is required for full repression through NRE(DIT) in Saccharomyces cerevisiae. Friesen, H., Tanny, J.C., Segall, J. Genetics (1998) [Pubmed]
  12. Identification and characterization of mutations affecting sporulation in Saccharomyces cerevisiae. Smith, L.M., Robbins, L.G., Kennedy, A., Magee, P.T. Genetics (1988) [Pubmed]
  13. Cloning of the STA2 and SGA genes encoding glucoamylases in yeasts and regulation of their expression by the STA10 gene of Saccharomyces cerevisiae. Pardo, J.M., Polaina, J., Jiménez, A. Nucleic Acids Res. (1986) [Pubmed]
  14. Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiae. Fares, H., Goetsch, L., Pringle, J.R. J. Cell Biol. (1996) [Pubmed]
  15. Metabolism of myo-inositol during sporulation of myo-inositol-requiring Saccharomyces cerevisiae. Schroeder, R., Breitenbach, M. J. Bacteriol. (1981) [Pubmed]
 
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