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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NOP53  -  Nop53p

Saccharomyces cerevisiae S288c

Synonyms: LPI2C, Nucleolar protein 53, P2610, Ribosome biogenesis protein NOP53, YPL146C
 
 
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High impact information on NOP53

  • Nop53p is required for late 60S ribosome subunit maturation and nuclear export in yeast [1].
  • Deletion or mutations within NOP53 cause significant growth defects and display significant 60 S subunit deficiencies, an imbalance in the 40 S:60 S ratio, as revealed by polysome profiling, and defects in progression beyond the 27 S stage of 25 S rRNA maturation during 60 S biogenesis [2].
  • A carbon source-conditional strain with the NOP53 coding sequence under the control of the GAL1 promoter did not grow in glucose-containing medium, showing the phenotype of an essential gene [3].
  • Specifically, Nop53p appears to be most important for biogenesis of the 60 S subunit [2].
  • Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein [2].

References

  1. Nop53p is required for late 60S ribosome subunit maturation and nuclear export in yeast. Thomson, E., Tollervey, D. RNA (2005) [Pubmed]
  2. Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein. Sydorskyy, Y., Dilworth, D.J., Halloran, B., Yi, E.C., Makhnevych, T., Wozniak, R.W., Aitchison, J.D. Biochem. J. (2005) [Pubmed]
  3. Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae. Granato, D.C., Gonzales, F.A., Luz, J.S., Cassiola, F., Machado-Santelli, G.M., Oliveira, C.C. FEBS J. (2005) [Pubmed]
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