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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KAP120  -  Kap120p

Saccharomyces cerevisiae S288c

Synonyms: Importin beta-like protein KAP120, Karyopherin-120, YPL125W
 
 
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High impact information on KAP120

  • The nuclear accumulation of 60S ribosomal subunits in kap120 mutants is abolished upon RPF1 overexpression, indicating that Kap120 does not function in the actual ribosomal export step but rather in import of ribosome maturation factors [1].
  • Similarly, KAP120 deletion rescues cells from zymocin, suggesting that Elongator's TOT function requires NLS- and karyopherin-dependent nuclear import [2].
  • MA utilizes Kap120p and Mtr10p import receptors while nuclear entry of NC involves the classical importin-alpha/beta (Kap60p/95p) pathway [3].
 

Anatomical context of KAP120

  • Here, we characterize Kap120 as an importin for the ribosome maturation factor Rpf1, which was identified in a two-hybrid screen [1].
 

Physical interactions of KAP120

References

  1. Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast. Caesar, S., Greiner, M., Schlenstedt, G. Mol. Cell. Biol. (2006) [Pubmed]
  2. Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification. Fichtner, L., Jablonowski, D., Schierhorn, A., Kitamoto, H.K., Stark, M.J., Schaffrath, R. Mol. Microbiol. (2003) [Pubmed]
  3. Importin-beta family members mediate alpharetrovirus gag nuclear entry via interactions with matrix and nucleocapsid. Butterfield-Gerson, K.L., Scheifele, L.Z., Ryan, E.P., Hopper, A.K., Parent, L.J. J. Virol. (2006) [Pubmed]
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