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Gene Review

LGE1  -  Lge1p

Saccharomyces cerevisiae S288c

Synonyms: Large cells protein 1, Transcriptional regulatory protein LGE1, YPL055C
 
 
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High impact information on LGE1

  • Large cells apparently become large as a consequence of a defect in DNA replication or nuclear division [1].
  • Notably, analysis of mutants demonstrates a function for Bre1/Lge1-dependent H2B monoubiquitination in the control of cell size [2].
  • Interestingly, rho(0) strains lacking Lge1p failed to induce PDR3 transcription, but induction was still seen in Deltarad6, Deltabre1, and H2B-K123R mutant strains [3].
  • Microarray experiments also confirmed that the pattern of gene expression changes seen in cells lacking Lge1p, Bre1p, or Rad6p or containing the H2B-K123R mutant as the only form of H2B share some overlap but are distinct [3].
  • Loss of the LGE1 gene led to a block in rho0-mediated induction of PDR5 expression [4].
 

Biological context of LGE1

  • Large cells with a similar appearance were also observed upon culture at 87 degrees C, suggesting the occurrence of similar cell fusions during growth [5].
  • Large cells, such as provided by polyploid strains, are also useful in yeast patch recording, especially while the skill required for gigaseal formation is being learned [6].
 

Other interactions of LGE1

  • We identify the novel protein Lge1p as a required participant in the rho(0) activation of PDR3 and PDR5 expression [3].
  • These findings provide a strong argument that Lge1p has roles in gene regulation independent of its participation in the Rad6p-dependent ubiquitination of H2B [3].

References

  1. Clonal lethality caused by the yeast plasmid 2 mu DNA. Holm, C. Cell (1982) [Pubmed]
  2. A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Hwang, W.W., Venkatasubrahmanyam, S., Ianculescu, A.G., Tong, A., Boone, C., Madhani, H.D. Mol. Cell (2003) [Pubmed]
  3. Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination. Zhang, X., Kolaczkowska, A., Devaux, F., Panwar, S.L., Hallstrom, T.C., Jacq, C., Moye-Rowley, W.S. J. Biol. Chem. (2005) [Pubmed]
  4. Retrograde regulation of multidrug resistance in Saccharomyces cerevisiae. Moye-Rowley, W.S. Gene (2005) [Pubmed]
  5. Thermococcus coalescens sp. nov., a cell-fusing hyperthermophilic archaeon from Suiyo Seamount. Kuwabara, T., Minaba, M., Iwayama, Y., Inouye, I., Nakashima, M., Marumo, K., Maruyama, A., Sugai, A., Itoh, T., Ishibashi, J., Urabe, T., Kamekura, M. Int. J. Syst. Evol. Microbiol. (2005) [Pubmed]
  6. Electrophysiology in the eukaryotic model cell Saccharomyces cerevisiae. Bertl, A., Bihler, H., Kettner, C., Slayman, C.L. Pflugers Arch. (1998) [Pubmed]
 
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