Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CTF19 - Ctf19p

Saccharomyces cerevisiae S288c

Synonyms: Central kinetochore subunit CTF19, Chromosome transmission fidelity protein 19, LPB13W, MCM18, Minichromosome maintenance protein 18, ...

Hyland, K.M. et al., Yoon, H.J. et al., Ortiz, J. et al., Jones, M.H. et al., Measday, V. et al.

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High impact information on CTF19

In contrast, Ctf3p and Ctf19p fail to bind properly to the centromere in a cse4-1 mutant strain [1].
A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore [2].
CTF19 genetically interacts with kinetochore structural mutants and mitotic checkpoint mutants [3].
CTF19 encodes a nonessential 369-amino acid protein. ctf19 mutant strains display a severe chromosome missegregation phenotype, are hypersensitive to benomyl, and accumulate at G2/M in cycling cells [3].
In addition, ctf19 mutants show a defect in the ability of centromeres on minichromosomes to bind microtubules in an in vitro assay [3].

Other interactions of CTF19

In addition, deletion of BIR1 is synthetically lethal with deletion of CBF1 or CTF19, genes specifying two other components of the yeast kinetochore [4].
We also demonstrate genetic interactions between DAM1 and CTF19 or SLK19 genes encoding kinetochore proteins [5].

Analytical, diagnostic and therapeutic context of CTF19

In vivo cross-linking and chromatin immunoprecipitation demonstrates that Ctf19p specifically interacts with CEN DNA [3].

References

Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Measday, V., Hailey, D.W., Pot, I., Givan, S.A., Hyland, K.M., Cagney, G., Fields, S., Davis, T.N., Hieter, P. Genes Dev. (2002) [Pubmed]
A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore. Ortiz, J., Stemmann, O., Rank, S., Lechner, J. Genes Dev. (1999) [Pubmed]
Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle. Hyland, K.M., Kingsbury, J., Koshland, D., Hieter, P. J. Cell Biol. (1999) [Pubmed]
Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events. Yoon, H.J., Carbon, J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle. Jones, M.H., He, X., Giddings, T.H., Winey, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]

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