The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

NCR1  -  Ncr1p

Saccharomyces cerevisiae S288c

Synonyms: Niemann-Pick type C-related protein 1, YPL006W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on NCR1

  • However, a dominant mutation in the putative sterol-sensing domain of Ncr1p conferred temperature and polyene antibiotic sensitivity without changes in sterol metabolism [1].
  • We find that one of these amino acid changes severely compromises Ncr1p function as assessed using the edelfosine resistance assay [2].
  • Ncr1p localizes to the vacuole, the yeast equivalent to the mammalian endosome-lysosome system [2].
  • We exploit the edelfosine resistance phenotype to assess the function of yeast Ncr1 proteins carrying amino acid changes corresponding to human NPC1 patient mutations [2].
  • Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport [3].

References

  1. Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. Malathi, K., Higaki, K., Tinkelenberg, A.H., Balderes, D.A., Almanzar-Paramio, D., Wilcox, L.J., Erdeniz, N., Redican, F., Padamsee, M., Liu, Y., Khan, S., Alcantara, F., Carstea, E.D., Morris, J.A., Sturley, S.L. J. Cell Biol. (2004) [Pubmed]
  2. A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p. Berger, A.C., Hanson, P.K., Wylie Nichols, J., Corbett, A.H. Traffic (2005) [Pubmed]
  3. Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport. Zhang, S., Ren, J., Li, H., Zhang, Q., Armstrong, J.S., Munn, A.L., Yang, H. Traffic (2004) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities