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Gene Review

ICL2  -  methylisocitrate lyase ICL2

Saccharomyces cerevisiae S288c

Synonyms: LPZ6C, Methylisocitrate lyase, Mitochondrial 2-methylisocitrate lyase, YP9723.06C, YPR006C
 
 
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High impact information on ICL2

 

Biological context of ICL2

 

Associations of ICL2 with chemical compounds

  • Thus, the results presented in this work argue for ICL2 encoding a non-functional isocitrate lyase and provide evidence that lysine 216 of Icl1 is not essential for catalysis [2].
  • In icl2 mutants, lack of ACS activity resulted in a non-induced glyoxylate cycle on acetate; however, induction on fatty acids was not affected [3].
 

Other interactions of ICL2

  • Gene ICL2 was identified as the structural gene encoding the monomer of ACS [3].

References

  1. The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism. Luttik, M.A., Kötter, P., Salomons, F.A., van der Klei, I.J., van Dijken, J.P., Pronk, J.T. J. Bacteriol. (2000) [Pubmed]
  2. Molecular genetics of ICL2, encoding a non-functional isocitrate lyase in Saccharomyces cerevisiae. Heinisch, J.J., Valdés, E., Alvarez, J., Rodicio, R. Yeast (1996) [Pubmed]
  3. Characterization of mutants of the yeast Yarrowia lipolytica defective in acetyl-coenzyme A synthetase. Kujau, M., Weber, H., Barth, G. Yeast (1992) [Pubmed]
 
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