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Gene Review

QCR2  -  ubiquinol--cytochrome-c reductase subunit 2

Saccharomyces cerevisiae S288c

Synonyms: COR2, Complex III subunit 2, Core protein II, Cytochrome b-c1 complex subunit 2, mitochondrial, P9677.6, ...
 
 
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High impact information on QCR2

  • The deduced amino acid sequences of the Drosophila and human proteins have considerable homology, extending beyond the putative catalytic region to include two novel, highly conserved, upstream conserved regions (UCR1 and UCR2) [1].
  • Internal deletions of either the C-terminal portion of UCR1 or the N-terminal portion of UCR2 abolishes dimerization of PDE4D3 indicating that both domains are involved in this intermolecular interaction [2].
  • UCR1 and UCR2 have been shown to form a module necessary for the activation of PDE4 upon phosphorylation by the cAMP-dependent kinase (PKA) [2].
  • Surprisingly, this amino acid replacement in cytochrome b corrects not only the phenotype resulting from the cor2-45 frameshift mutation, but it also obviates the need for core protein 2 in the cytochrome bc1 complex since it alleviates the respiratory deficiency resulting from the complete deletion of the COR2 gene [3].
  • The loss of respiration is more severe with this frameshift mutation than with the complete deletion of the COR2 gene, suggesting deleterious effects of the truncated core 2 protein [3].
 

Biological context of QCR2

References

 
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