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Gene Review

NEM1  -  Nem1p

Saccharomyces cerevisiae S288c

Synonyms: Nuclear envelope morphology protein 1, YHR004C
 
 
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High impact information on NEM1

  • We show that Smp2 associates with the promoters of phospholipid biosynthetic enzymes in a Nem1-Spo7-dependent manner [1].
  • Nem1p binds to Spo7p via its conserved C-terminal domain [2].
  • Psr1p and Psr2p are highly homologous and were identified through their homology with the endoplasmic reticulum membrane protein Nem1p [3].
 

Anatomical context of NEM1

  • Although cells without Spo7p or Nem1p are viable, they exhibit a drastically altered nuclear morphology with long, pore-containing double nuclear membrane extensions [2].
 

Other interactions of NEM1

  • One component is a known sporulation factor Spo7p, and the other, Nem1p, a novel protein whose C-terminal domain is conserved during eukaryotic evolution [2].

References

  1. The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth. Santos-Rosa, H., Leung, J., Grimsey, N., Peak-Chew, S., Siniossoglou, S. EMBO J. (2005) [Pubmed]
  2. A novel complex of membrane proteins required for formation of a spherical nucleus. Siniossoglou, S., Santos-Rosa, H., Rappsilber, J., Mann, M., Hurt, E. EMBO J. (1998) [Pubmed]
  3. Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. Siniossoglou, S., Hurt, E.C., Pelham, H.R. J. Biol. Chem. (2000) [Pubmed]
 
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