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Gene Review

BIG1  -  Big1p

Saccharomyces cerevisiae S288c

Synonyms: Bad in glucose protein 1, Protein BIG1, YHR101C
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High impact information on BIG1

  • The wild-type ROT1 and ROT2 genes and a multicopy suppressor, BIG1, were isolated by their ability to rescue the rot1-1 rot2-1 double mutant [1].
  • ROT2 encodes glucosidase II, and ROT1 and BIG1 encode novel proteins [1].
  • A specific localization of CaBig1p at the endoplasmic reticulum or plasma membrane similar to the subcellular localization of S. cerevisiae Big1p was observed in yeast form [2].
  • Furthermore, the phenotypes of rot1Delta cells resemble those of disruption mutants of the KRE5 and BIG1 genes, which show greatly reduced levels of cell wall 1,6-beta-glucan [3].
  • Deletion of Saccharomyces cerevisiae BIG1 causes an approximately 95% reduction in cell wall beta-1,6-glucan, an essential polymer involved in the cell wall attachment of many surface mannoproteins [4].

Anatomical context of BIG1


Other interactions of BIG1

  • The indispensability of BIG1 and KRE6 for the viability of gas1Delta cells confirmed the important role of beta-1,6-glucan in cells that are defective in the processing of beta-1,3-glucan [5].


  1. Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. Bickle, M., Delley, P.A., Schmidt, A., Hall, M.N. EMBO J. (1998) [Pubmed]
  2. Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans. Umeyama, T., Kaneko, A., Watanabe, H., Hirai, A., Uehara, Y., Niimi, M., Azuma, M. Infect. Immun. (2006) [Pubmed]
  3. Rot1p of Saccharomyces cerevisiae is a putative membrane protein required for normal levels of the cell wall 1,6-beta-glucan. Machi, K., Azuma, M., Igarashi, K., Matsumoto, T., Fukuda, H., Kondo, A., Ooshima, H. Microbiology (Reading, Engl.) (2004) [Pubmed]
  4. Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan. Azuma, M., Levinson, J.N., Pagé, N., Bussey, H. Yeast (2002) [Pubmed]
  5. Mutations that are synthetically lethal with a gas1Delta allele cause defects in the cell wall of Saccharomyces cerevisiae. Tomishige, N., Noda, Y., Adachi, H., Shimoi, H., Takatsuki, A., Yoda, K. Mol. Genet. Genomics (2003) [Pubmed]
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