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Gene Review

UBA4  -  Uba4p

Saccharomyces cerevisiae S288c

Synonyms: Adenylyltransferase and sulfurtransferase UBA4, NCS3, Needs CLA4 to survive protein 3, Ubiquitin-like protein activator 4, YHR111W
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High impact information on UBA4

  • At the first step of this reaction, Urm1 forms a thioester with a novel E1-like protein, Uba4 [1].

Associations of UBA4 with chemical compounds

  • Urm1 and Uba4 show similarity to prokaryotic proteins essential for molybdopterin and thiamin biosynthesis, although the Urm1 system is not involved in these pathways [1].


  1. A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes. Furukawa, K., Mizushima, N., Noda, T., Ohsumi, Y. J. Biol. Chem. (2000) [Pubmed]
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