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Gene Review

ANP1  -  Anp1p

Saccharomyces cerevisiae S288c

Synonyms: Aminonitrophenyl propanediol resistance protein, GEM3, M-Pol II subunit ANP1, MNN8, Mannan polymerase II complex ANP1 subunit, ...
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High impact information on ANP1

  • The CYC7-H3 deletion encompasses the RAD23 locus, which controls UV sensitivity and the ANP1 locus, which controls osmotic sensitivity [1].
  • Anp1p, Van1p and Mnn9p constitute a family of membrane proteins required for proper Golgi function in Saccharomyces cerevisiae [2].
  • The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway [3].
  • Interestingly, Anp1p is localized to the endoplasmic reticulum (ER), implying that some function of the ER is required to maintain a functional Golgi apparatus [3].
  • We have mapped the mcm3-1 mutation of the left arm of chromosome V approximately 3 kb centromere proximal of anp1 [4].

Biological context of ANP1


Co-localisations of ANP1

  • In addition, Hoc1 protein which has significant homology to Och1 protein colocalized with Anp1 and Mnn9 proteins [6].

Other interactions of ANP1

  • Also translated regions of the COR gene RAD7 share similarities with both of the two adjacent ARC genes, ANP1 and RAD23 [7].
  • The previously published VAN1 gene product has a 200 amino acid domain with 40% identity with the MNN9 gene product and 70% identity with the ANP1 gene product [8].
  • Analysis of interactions between the proteins in this complex shows that Mnn10p, and four previously characterized proteins (Anp1p, Mnn9p, Mnn11p, and Hoc1p) are indeed all components of the same large structure [9].
  • In this study, the identification and characterization of the Yarrowia lipolytica homologues of Saccharomyces cerevisiae alpha-1,6-mannosyltransferases Anp1p and Och1p, designated YlAnl1p and YlOch1p, are described [10].


  1. An extensive deletion causing overproduction of yeast iso-2-cytochrome c. McKnight, G.L., Cardillo, T.S., Sherman, F. Cell (1981) [Pubmed]
  2. Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity. Jungmann, J., Munro, S. EMBO J. (1998) [Pubmed]
  3. The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway. Chapman, R.E., Munro, S. EMBO J. (1994) [Pubmed]
  4. The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication. Gibson, S.I., Surosky, R.T., Tye, B.K. Mol. Cell. Biol. (1990) [Pubmed]
  5. Identification of functional connections between calmodulin and the yeast actin cytoskeleton. Sekiya-Kawasaki, M., Botstein, D., Ohya, Y. Genetics (1998) [Pubmed]
  6. Novel membrane protein complexes for protein glycosylation in the yeast Golgi apparatus. Hashimoto, H., Yoda, K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  7. The gene clusters ARC and COR on chromosomes 5 and 10, respectively, of Saccharomyces cerevisiae share a common ancestry. Melnick, L., Sherman, F. J. Mol. Biol. (1993) [Pubmed]
  8. Sodium orthovanadate-resistant mutants of Saccharomyces cerevisiae show defects in Golgi-mediated protein glycosylation, sporulation and detergent resistance. Kanik-Ennulat, C., Montalvo, E., Neff, N. Genetics (1995) [Pubmed]
  9. The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex. Jungmann, J., Rayner, J.C., Munro, S. J. Biol. Chem. (1999) [Pubmed]
  10. Identification and characterization of two alpha-1,6-mannosyltransferases, Anl1p and Och1p, in the yeast Yarrowia lipolytica. Barnay-Verdier, S., Boisramé, A., Beckerich, J.M. Microbiology (Reading, Engl.) (2004) [Pubmed]
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