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Gene Review

PRE1  -  proteasome core particle subunit beta 4

Saccharomyces cerevisiae S288c

Synonyms: Macropain subunit C11, Multicatalytic endopeptidase complex subunit C11, Proteasome component C11, Proteasome subunit beta type-4, Proteinase YSCE subunit 11, ...
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High impact information on PRE1

  • The mutants show a specific reduction in the activity of the complex against peptide substrates with hydrophobic amino acids at the cleavage site and define two complementation groups, PRE1 and PRE2 [1].
  • The deduced amino acid sequence encoded by the PRE1 gene reveals weak, but significant similarities to proteasome subunits of other organisms [1].
  • It has been suggested that in S. macrospora, PPG1/PRE2 and PPG2/PRE1 form two cognate pheromone-receptor pairs [2].
  • The deduced pre1 gene product is a putative seven-transmembrane protein, which displays a high-level amino acid identity with the a-factor receptor Ste3p of Saccharomyces cerevisiae, and is also homologous to lipopeptide pheromone receptors of basidiomycetes [3].
  • We have identified two pheromone receptor genes, named pre1 and pre2, in the genome of the heterothallic filamentous ascomycete Neurospora crassa and the closely related homothallic Sordaria macrospora [3].

Biological context of PRE1

  • Using strains carrying mutations in END3, REN1(VPS2), PEP4, and PRE1 PRE2, we demonstrate that the proteolysis of Mal61/HAp is dependent on endocytosis and vacuolar proteolysis and is independent of the proteosome [4].

Other interactions of PRE1

  • PRP22 is adjacent to PRE1, whose chromosomal location is currently unknown [5].


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