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GCD11  -  translation initiation factor eIF2 subunit...

Saccharomyces cerevisiae S288c

Synonyms: Eukaryotic translation initiation factor 2 subunit gamma, TIF213, YER025W, eIF-2-gamma
 
 
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High impact information on GCD11

  • The SUI4 suppressor gene is identical to the GCD11 gene, which encodes the gamma subunit of the eIF-2 complex and contains a mutation in the G2 motif, one of the four signature motifs that characterizes this subunit to be a G-protein [1].
  • Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis [2].
  • In a previous report, we identified GCD11 as an essential gene encoding the gamma subunit of eIF-2 in the yeast Saccharomyces cerevisiae [2].
  • The predicted amino acid sequence of yeast eIF-2 gamma displays remarkable similarity to bacterial elongation factor Tu, including the presence of sequence elements conserved in all known guanine nucleotide binding proteins [2].
  • Three of these mutations result in amino acid substitutions within the putative GTP binding domain of eIF-2 gamma [2].
 

Biological context of GCD11

  • The nucleotide sequence of the cloned GCD11 gene predicts a 527-amino-acid polypeptide that is similar to the prokaryotic translation elongation factor EF-Tu [3].
  • Mutations in the yeast GCD11 gene have been shown to confer a similar phenotype [3].
 

Associations of GCD11 with chemical compounds

  • Relative to EF-Tu, the deduced GCD11 amino acid sequence contains a 90-amino-acid N-terminal extension and an internal cysteine-rich sequence that contains a potential metal-binding finger motif [3].

References

 
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