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Gene Review

UBC6  -  E2 ubiquitin-conjugating protein UBC6

Saccharomyces cerevisiae S288c

Synonyms: DOA2, Ubiquitin carrier protein UBC6, Ubiquitin-conjugating enzyme E2 6, Ubiquitin-protein ligase UBC6, YER100W
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High impact information on UBC6

  • This suggests that UBC6 may mediate selective degradation of ER membrane proteins and that the protein translocation defect of sec61 may be caused by proteolysis of components of a structurally distorted mutant translocation apparatus [1].
  • Doa10 functions with two E2s, Ubc6 and Ubc7, to ubiquitinate Deg1-bearing substrates, and it is also required for the degradation of at least one ER membrane protein [2].
  • UBC6 lacks a lumenal domain and contains no known endoplasmic reticulum retention signals [3].
  • The basis for the transmembrane domain-mediated subcellular targeting of UBC6 was evaluated by lengthening the wild type UBC6 hydrophobic segment from 17 to 21 amino acids, which resulted in re-targeting to the Golgi complex [3].
  • The similarity of this region with sequences contained within the tails of the UBC1 and UBC6 enzymes suggests that these tails may function in a similar manner [4].

Biological context of UBC6


Other interactions of UBC6

  • Both mps2-1 and ndc1-1 are also suppressed by disruption of UBC7 or its partner, UBC6 [6].


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