Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

SCS2 - Scs2p

Saccharomyces cerevisiae S288c

Synonyms: Choline sensitivity suppressor protein 2, VAMP-associated protein SCS2, VAP homolog 1, Vesicle-associated membrane protein-associated protein SCS2, YER120W

Craven, R.J. et al., Nikawa, J. et al., Loewen, C.J. et al., Cuperus, G. et al., Brickner, J.H. et al.

Brickner, Walter,

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High impact information on SCS2

Here we have studied the FFAT-VAP interaction in Saccharomyces cerevisiae, where the VAP homologue Scs2 regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1 [1].
Elevated dosage of SCS2, previously implicated as a regulator of both inositol biosynthesis and telomeric silencing, suppressed the dominant-negative effect of a SIR2-143 mutation [2].
The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects [3].
We identified SCS2 (suppressor of choline sensitivity), a gene previously isolated as a suppressor of defects in inositol synthesis [3].
Deletion of SCS2 resulted in decreased telomeric silencing, and the scs2 mutation increased the rate of cellular senescence observed for mec1-21 tel1 double mutant cells [3].

Anatomical context of SCS2

Here we show that activation of INO1 occurs at the nuclear membrane and requires the integral membrane protein Scs2 [4].

Associations of SCS2 with chemical compounds

Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae [5].
Among them, one gene, designated as SCS2, also suppressed the choline-sensitive dominant mutation, CSE1 [Hosaka, K. et al. (1992) J. Biochem. 111, 352-358] [5].

References

A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. Loewen, C.J., Levine, T.P. J. Biol. Chem. (2005) [Pubmed]
Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8. Cuperus, G., Shore, D. Genetics (2002) [Pubmed]
The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects. Craven, R.J., Petes, T.D. Genetics (2001) [Pubmed]
Gene recruitment of the activated INO1 locus to the nuclear membrane. Brickner, J.H., Walter, P. PLoS Biol. (2004) [Pubmed]
Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae. Nikawa, J., Murakami, A., Esumi, E., Hosaka, K. J. Biochem. (1995) [Pubmed]

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