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Gene Review:

tetC - tetracycline-resistance protein

Francisella tularensis

Pomerantsev, A.P. et al., Pavlov, V.M. et al.

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Disease relevance of tetC

Expression of the tetC gene is regulated by an Escherichia coli sigma(70)-like promoter and is dependent on the F. tularensis strain and its environment [1].
pOM1 is a recombinant 4442-bp plasmid that includes the replicon of the Francisella novicida-like strain F6168 cryptic plasmid pFNL10 and the tetracycline resistance gene (tetC) of plasmid pBR328. pOM1 can stably replicate and is maintained in Francisella tularensis biovars tularensis, palaearctica, and palaearctica var. japonica [1].

Chemical compound and disease context of tetC

This plasmid was able to replicate and to express the genes for chloramphenicol and tetracycline resistance in both E. coli and F. tularensis [2].

References

Nucleotide sequence, structural organization, and functional characterization of the small recombinant plasmid pOM1 that is specific for Francisella tularensis. Pomerantsev, A.P., Obuchi, M., Ohara, Y. Plasmid (2001) [Pubmed]
Cryptic plasmid pFNL10 from Francisella novicida-like F6168: the base of plasmid vectors for Francisella tularensis. Pavlov, V.M., Mokrievich, A.N., Volkovoy, K. FEMS Immunol. Med. Microbiol. (1996) [Pubmed]

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