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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mucA  -  putative UV protection protein

Salmonella enterica subsp. enterica serovar Typhi

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Disease relevance of mucA

  • When assayed on supplemented selective medium, the E. coli strain IC3821 (trpE65), carrying the delta oxyR30 mutation and containing the plasmid pRW144 (mucA/B), showed a frequency of spontaneous Trp+ revertants similar to that of the oxyR+ control [1].
 

High impact information on mucA

  • Thus, NUV lesions did not lead to induction of SOS repair and subsequent expression of mucA and B genes on plasmid pKM101 [2].
 

Biological context of mucA

  • Plasmid pKM101, whose mucA and B genes endow cells with enhanced mutation frequency and enhanced resistance to far-ultraviolet radiation (FUV) (254 nm), had no influence on these properties when cells were damaged by near-ultraviolet radiation (NUV) (300-400 nm) [2].

References

  1. Increased mutability by oxidative stress in OxyR-deficient Escherichia coli and Salmonella typhimurium cells: clonal occurrence of the mutants during growth on nonselective media. Blanco, M., Herrera, G., Urios, A. Mutat. Res. (1995) [Pubmed]
  2. Genetic damage in Salmonella typhimurium by near-ultraviolet radiation. Lack of repair by plasmid pKM101. Eisenstark, A. Mutat. Res. (1983) [Pubmed]
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