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Gene Review

mxiA  -  invasion protein

Shigella flexneri 5a str. M90T

 
 
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Disease relevance of mxiA

  • mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis [1].
  • The plasmid-encoded invasion plasmid antigen (Ipa) export accessory locus of Shigella flexneri 2a, mxiA, was cloned, and the complete DNA sequence of the gene was determined [1].
  • In contrast, the overexpression of mxiA that resulted when it was placed under the control of the lac promoter was found to be deleterious in Escherichia coli [1].
  • High Resolution Structure of BipD: An Invasion Protein Associated with the Type III Secretion System of Burkholderia Pseudomallei [2].
 

High impact information on mxiA

  • We detected series of 9 or 10 As in spa13, spa33 and mxiA encoding type III secretion apparatus components [3].
  • Two strains were found in the pINV B form by using the ipgD sequence, with one strain having an mxiA sequence similar to the divergent sequence of D1 [4].
  • While a homology search did not reveal any significant relatedness of the mxiA DNA sequence to any known bacterial gene sequences, the derived amino acid sequence of MxiA was found to be highly homologous (68%) to the sequence of the protein encoded by the low-calcium-response locus, lcrD, of Yersinia pestis [1].
  • Congo red binding, HeLa cell invasion, and Ipa excretion were restored in two avirulent mxiA fusion mutants when they were transformed with a cloned copy of the mxiA gene [1].

References

  1. mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis. Andrews, G.P., Maurelli, A.T. Infect. Immun. (1992) [Pubmed]
  2. High Resolution Structure of BipD: An Invasion Protein Associated with the Type III Secretion System of Burkholderia Pseudomallei. Erskine, P.T., Knight, M.J., Ruaux, A., Mikolajek, H., Sang, N.W., Withers, J., Gill, R., Wood, S.P., Wood, M., Fox, G.C., Cooper, J.B. J. Mol. Biol. (2006) [Pubmed]
  3. Transcriptional slippage controls production of type III secretion apparatus components in Shigella flexneri. Penno, C., Hachani, A., Biskri, L., Sansonetti, P., Allaoui, A., Parsot, C. Mol. Microbiol. (2006) [Pubmed]
  4. Molecular evolutionary relationships of enteroinvasive Escherichia coli and Shigella spp. Lan, R., Alles, M.C., Donohoe, K., Martinez, M.B., Reeves, P.R. Infect. Immun. (2004) [Pubmed]
 
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