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Gene Review:

ipaH9.8 - invasion plasmid antigen

Shigella flexneri 5a str. M90T

Kato, J. et al., Demers, B. et al., Kueltzo, L.A. et al.

Demers, Sansonetti, Parsot,

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Disease relevance of ipaH9.8

Invasion plasmid antigen C (IpaC) has been identified as the primary effector protein for Shigella invasion of epithelial cells [1].
The first region was cloned into an E. coli HB101 strain containing noninvasive Tn1 insertion mutants of the form I plasmid, and expression of ipa (invasion plasmid antigen) gene products was restored [2].

High impact information on ipaH9.8

In this study, we have identified secreted proteins of 46 and 60 kDa as the products of virA and ipaH9.8, respectively, the latter being a member of the ipaH multigene family [3].

References

Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri. Kueltzo, L.A., Osiecki, J., Barker, J., Picking, W.L., Ersoy, B., Picking, W.D., Middaugh, C.R. J. Biol. Chem. (2003) [Pubmed]
Cloning of regions required for contact hemolysis and entry into LLC-MK2 cells from Shigella sonnei form I plasmid: virF is a positive regulator gene for these phenotypes. Kato, J., Ito, K., Nakamura, A., Watanabe, H. Infect. Immun. (1989) [Pubmed]
Induction of type III secretion in Shigella flexneri is associated with differential control of transcription of genes encoding secreted proteins. Demers, B., Sansonetti, P.J., Parsot, C. EMBO J. (1998) [Pubmed]

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