Gene Review:
MPN372 - toxin subunit s1
Mycoplasma pneumoniae M129
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Disease relevance of MPN372
- Within its N terminus, MPN372 contains key amino acids associated with NAD binding and ADP-ribosylating activity, similar to pertussis toxin (PTX) S1 subunit (PTX-S1) [1].
High impact information on MPN372
- Here, we report the identification of a virulence factor (MPN372) possibly responsible for airway cellular damage and other sequelae associated with M. pneumoniae infections in humans [1].
- Remarkably, MPN372 elicits extensive vacuolization and ultimate cell death of mammalian cells, including distinct and progressive patterns of cytopathology in tracheal rings in organ culture that had been previously ascribed to infection with WT virulent M. pneumoniae [1].
References
- ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens. Kannan, T.R., Baseman, J.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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