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Gene Review

xcpR  -  general secretion pathway protein E

Pseudomonas aeruginosa PAO1

 
 
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High impact information on xcpR

  • The xcp locus located at 40 min on the chromosome consists of two divergently transcribed operons, namely xcpPQ and xcpR to xcpZ [1].
  • Furthermore, introduction of the lasR mutation in PANO67 results in additional diminution of xcpR transcription, indicating that the two systems can regulate their target genes independently [1].
  • Here the nucleotide sequences of seven other xcp genes, designated xcpR to -X, are presented [2].
  • One of the components of this machinery is the product of the xcpR gene, which is homologous to pilB, a gene encoding a protein essential for the biogenesis of type IV pili [3].
 

Associations of xcpR with chemical compounds

  • The codons of highly conserved glycine residues within the Walker sequences of xcpR and pilB were altered to encode a serine, and the effects of these substitutions were examined [3].

References

  1. Regulation of the xcp secretion pathway by multiple quorum-sensing modulons in Pseudomonas aeruginosa. Chapon-Hervé, V., Akrim, M., Latifi, A., Williams, P., Lazdunski, A., Bally, M. Mol. Microbiol. (1997) [Pubmed]
  2. Protein secretion in Pseudomonas aeruginosa: characterization of seven xcp genes and processing of secretory apparatus components by prepilin peptidase. Bally, M., Filloux, A., Akrim, M., Ball, G., Lazdunski, A., Tommassen, J. Mol. Microbiol. (1992) [Pubmed]
  3. Mutations in the consensus ATP-binding sites of XcpR and PilB eliminate extracellular protein secretion and pilus biogenesis in Pseudomonas aeruginosa. Turner, L.R., Lara, J.C., Nunn, D.N., Lory, S. J. Bacteriol. (1993) [Pubmed]
 
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