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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

prc  -  periplasmic tail-specific protease

Pseudomonas aeruginosa PAO1

 
 
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High impact information on prc

  • In addition, a mutation in gene PA3257 (prc), encoding a Prc-like protease, resulted in poor induction of PalgD-cat by d-cycloserine, suggesting that it also plays a role in the response to cell wall stress [1].
  • Sequencing of prc from three strains with som suppressor mutations confirmed that each had a mutation within the prc coding region [2].
  • PA3257 (prc) was identified as a regulator of alginate production in P. aeruginosa through the isolation and study of mutations that partially suppressed the mucoid phenotype of a mucA22 strain [2].

References

  1. Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: roles of sigma (AlgT) and the AlgW and Prc proteases. Wood, L.F., Leech, A.J., Ohman, D.E. Mol. Microbiol. (2006) [Pubmed]
  2. Prc protease promotes mucoidy in mucA mutants of Pseudomonas aeruginosa. Reiling, S.A., Jansen, J.A., Henley, B.J., Singh, S., Chattin, C., Chandler, M., Rowen, D.W. Microbiology (Reading, Engl.) (2005) [Pubmed]
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