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Gene Review

Rv2377c  -  hypothetical protein

Mycobacterium tuberculosis H37Rv

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Disease relevance of mbtH

  • The balhimycin biosynthetic gene cluster of the glycopeptide producer Amycolatopsis balhimycina includes a gene (orf1) with unknown function. orf1 shows high similarity to the mbtH gene from Mycobacterium tuberculosis [1].

High impact information on mbtH


Biological context of mbtH

  • The mbtH-like gene is always colocalized with the NRPS genes; however, it does not have a specific position in the gene cluster [1].


  1. The small MbtH-like protein encoded by an internal gene of the balhimycin biosynthetic gene cluster is not required for glycopeptide production. Stegmann, E., Rausch, C., Stockert, S., Burkert, D., Wohlleben, W. FEMS Microbiol. Lett. (2006) [Pubmed]
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