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Gene Review

plcA  -  membrane-associated phospholipase A

Mycobacterium tuberculosis H37Rv

 
 
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Disease relevance of plcA

 

High impact information on plcA

  • Inactivation of the PLCs of MTB and insertion of the plcA gene into M. smegmatis resulted in a substantial reduction and increase in hydrolysis of phosphatidylcholine (PC), respectively [2].
  • The high level of transposition in the phospholipase region can lead to the excision of fragments of genomic DNA by recombination of neighboring IS6110 elements, as demonstrated by finding the deletion, in two strains, of a 2,837-bp fragment that included plcA and most of plcB [3].
  • We observed insertion elements in the plcA, plcB, and plcC genes [3].
 

Biological context of plcA

 

Other interactions of plcA

  • RESULTS: PCR amplification of this region demonstrated a complete lack of plcA and plcB ORF's in all of the isolates [1].

References

  1. Genetic characterization of Mycobacterium tuberculosis clinical isolates with deletions in the plcA-plcB-plcC locus. Vera-Cabrera, L., Molina-Torres, C.A., Hern??ndez-Vera, M.A., Barrios-Garc??a, H.B., Blackwood, K., Villareal-Trevi??o, L., Ocampo-Candiani, J., Welsh, O., Castro-Garza, J. Tuberculosis (Edinburgh, Scotland) (2007) [Pubmed]
  2. Antimicrobial activity of clofazimine is not dependent on mycobacterial C-type phospholipases. Bopape, M.C., Steel, H.C., Cockeran, R., Matlola, N.M., Fourie, P.B., Anderson, R. J. Antimicrob. Chemother. (2004) [Pubmed]
  3. Phospholipase region of Mycobacterium tuberculosis is a preferential locus for IS6110 transposition. Vera-Cabrera, L., Hernández-Vera, M.A., Welsh, O., Johnson, W.M., Castro-Garza, J. J. Clin. Microbiol. (2001) [Pubmed]
 
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