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TM4SF5  -  transmembrane 4 L six family member 5

Homo sapiens

Synonyms: Tetraspan transmembrane protein L6H, Transmembrane 4 L6 family member 5
 
 
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Disease relevance of TM4SF5

 

High impact information on TM4SF5

 

Biological context of TM4SF5

  • Using a radiation hybrid panel the identified human gene named TM4SF5 (transmembrane 4 superfamily member 5) was localized to chromosome 17 in the region 17p13 [1].
  • The predicted TM4SF5 protein with 197 amino acids contains three NH2-terminal hydrophobic transmembrane regions, followed by an extracellular hydrophilic domain containing two potential N-linked glycosylation sites and a COOH-terminal hydrophobic transmembrane region [1].
  • 3. The cloned TM4SF5 cDNA has a 32bp 5'-untranslated region (UTR), a 591bp open reading frame (ORF) and a 85bp 3'UTR [1].
 

Anatomical context of TM4SF5

  • Altogether, this study reveals the functions of TM4SF5 collaborative with integrin signaling to alter focal contact dynamics, actin reorganization, and migration [2].
 

Associations of TM4SF5 with chemical compounds

  • TM4SF5 associated with integrin alpha2 subunit, and this association was abolished by serum treatment [2].
 

Other interactions of TM4SF5

References

  1. Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. Müller-Pillasch, F., Wallrapp, C., Lacher, U., Friess, H., Büchler, M., Adler, G., Gress, T.M. Gene (1998) [Pubmed]
  2. Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment. Lee, S.Y., Kim, Y.T., Lee, M.S., Kim, Y.B., Chung, E., Kim, S., Lee, J.W. Exp. Cell Res. (2006) [Pubmed]
  3. Identification of genes associated with the corticotroph phenotype in bronchial carcinoid tumors. Pascual-Le Tallec, L., Dulmet, E., Bertagna, X., de Keyzer, Y. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  4. The L6 membrane proteins--a new four-transmembrane superfamily. Wright, M.D., Ni, J., Rudy, G.B. Protein Sci. (2000) [Pubmed]
 
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