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Gene Review:

L - RNA-dependent RNA polymerase

Zaire ebolavirus

Volchkov, V.E. et al., Geisbert, T.W. et al.

Geisbert, Hensley, Kagan, Yu, Geisbert, Daddario-DiCaprio, Fritz, Jahrling, McClintock, Phelps, Lee, Judge, Jeffs, MacLachlan,

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Disease relevance of L

Analysis of mRNA produced by T7 and vaccinia virus polymerase from the 7A's construct revealed that 1-5% contained alterations at the same site that was also edited by the Ebola virus polymerase [1].

High impact information on L

METHODS: Four siRNAs targeting the polymerase (L) gene of the Zaire species of EBOV (ZEBOV) were either complexed with polyethylenimine (PEI) or formulated in stable nucleic acid-lipid particles (SNALPs) [2].
GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases [1].
Our data indicate that the editing site in the Ebola virus glycoprotein gene is recognized not only by Ebola virus polymerase but also by DNA-dependent RNA polymerases of different origin [1].

References

GP mRNA of Ebola virus is edited by the Ebola virus polymerase and by T7 and vaccinia virus polymerases. Volchkov, V.E., Becker, S., Volchkova, V.A., Ternovoj, V.A., Kotov, A.N., Netesov, S.V., Klenk, H.D. Virology (1995) [Pubmed]
Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference. Geisbert, T.W., Hensley, L.E., Kagan, E., Yu, E.Z., Geisbert, J.B., Daddario-DiCaprio, K., Fritz, E.A., Jahrling, P.B., McClintock, K., Phelps, J.R., Lee, A.C., Judge, A., Jeffs, L.B., MacLachlan, I. J. Infect. Dis. (2006) [Pubmed]

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