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Gene Review:

tilS - tRNA(Ile)-lysidine synthetase

Escherichia coli O157:H7 str. Sakai

Kail, M. et al., Ikeuchi, Y. et al., Nakanishi, K. et al.

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Disease relevance of ECs0190

Escherichia coli TilS (called MesJ) has an additional CTD, which may recognize the tRNA(Ile)(2) acceptor stem [1].
The first is related to an uncharacterized ORF of Bacillus subtilis and more weakly to MesJ in Escherichia coli; this is found as a single transcript of 1.1 kb by Northern blotting [2].

High impact information on ECs0190

We previously identified tRNA(Ile)-lysidine synthetase (tilS) that synthesizes lysidine, for which it utilizes ATP and lysine as substrates [3].

References

Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. Nakanishi, K., Fukai, S., Ikeuchi, Y., Soma, A., Sekine, Y., Suzuki, T., Nureki, O. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Lambda clone B22 contains a 7676 bp genomic fragment of Saccharomyces cerevisiae chromosome VII spanning the VAM7-SPM2 intergenic region and containing three novel transcribed open reading frames. Kail, M., Jüttner, E., Vaux, D. Yeast (1996) [Pubmed]
molecular mechanism of lysidine synthesis that determines tRNA identity and codon recognition. Ikeuchi, Y., Soma, A., Ote, T., Kato, J., Sekine, Y., Suzuki, T. Mol. Cell (2005) [Pubmed]

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