Gene Review:
ECs4559 - gamma intimin
Escherichia coli O157:H7 str. Sakai
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Disease relevance of ECs4559
- The gamma intimin sequences from E. coli strains with serotypes O157:H7, O55:H7, and O157:H- are virtually identical, supporting the hypothesis that these bacteria belong to a single clonal lineage [1].
High impact information on ECs4559
- Nucleotide sequences of eae of three EPEC and four EHEC strains representing distinct clonal lineages revealed an exceptionally high level of divergence (15%) in the amino acid sequences of alpha, beta, and gamma intimin molecules, most of which is concentrated in the C-terminal region [1].
References
- Molecular evolution and mosaic structure of alpha, beta, and gamma intimins of pathogenic Escherichia coli. McGraw, E.A., Li, J., Selander, R.K., Whittam, T.S. Mol. Biol. Evol. (1999) [Pubmed]
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