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Gene Review:

aroQ - 3-dehydroquinate dehydratase

Mycobacterium tuberculosis CDC1551

Simmons, C.P. et al., Lalonde, G. et al.

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Disease relevance of aroQ

The 1.8 kb fragment, which includes aroQ, carries four overlapping or adjacent open reading frames: a dapD gene; aroQ; one without homology to sequences in GenBank; and one with homology to the C-terminal 40% of chIN of E. coli [1].
Attenuation and vaccine potential of aroQ mutants of Corynebacterium pseudotuberculosis [2].
This is the first report of an aroQ mutant of a bacterial pathogen, and the results may have implications for the construction of aromatic mutants of Mycobacterium tuberculosis for use as vaccines [2].

High impact information on aroQ

We have cloned and sequenced the aroB and aroQ genes from C. pseudotuberculosis C231 [2].
The in vivo persistence of these strains was increased when the intact aroQ gene was supplied on a plasmid in trans [2].

References

Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE. Lalonde, G., O'Hanley, P.D., Stocker, B.A., Denich, K.T. Mol. Microbiol. (1994) [Pubmed]
Attenuation and vaccine potential of aroQ mutants of Corynebacterium pseudotuberculosis. Simmons, C.P., Hodgson, A.L., Strugnell, R.A. Infect. Immun. (1997) [Pubmed]

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