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Gene Review:

gltA - type II citrate synthase

Rickettsia conorii str. Malish 7

Zhu, Y. et al., Kuloglu, F. et al., Morita, C. et al., Bernasconi, M.V. et al.

Bernasconi, Casati, Péter, Piffaretti, Zhu, Fournier, Eremeeva, Raoult,

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Disease relevance of gltA

PCR experiments of skin biopsies were positive in six (60%) of 10 skin biopsy samples and DNA sequencing of the positive PCR products gave 100% homology with Rickettsia conorii Malish 7 for opmA and gltA [1].
(using 16S rDNA, gltA and OmpA genes) as well as Coxiella sp. (using 16S rDNA) [2].

High impact information on gltA

Among these four MLST genotypes, the pairwise similarity in nucleotide sequence varied from 99.8 to 100%, 99.4 to 100%, 98.2 to 99.8%, 98.4 to 99.8%, and 99.2 to 99.9% for 16S rDNA, gltA, ompA, ompB, and sca4 genes, respectively [3].
Primer pairs of rickettsial citrate synthase gene (gltA) and a spotted fever group (SFG) rickettsial 190-kDa surface antigen gene (rompA), respectively, were used for identification [4].

References

Prospective evaluation of rickettsioses in the trakya (European) region of Turkey and atypic presentations of rickettsia conorii. Kuloglu, F., Rolain, J.M., Aydoslu, B., Akata, F., Tugrul, M., Raoult, D. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
Rhipicephalus ticks infected with Rickettsia and Coxiella in Southern Switzerland (Canton Ticino). Bernasconi, M.V., Casati, S., Péter, O., Piffaretti, J.C. Infect. Genet. Evol. (2002) [Pubmed]
Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conorii. Zhu, Y., Fournier, P.E., Eremeeva, M., Raoult, D. BMC Microbiol. (2005) [Pubmed]
Spotted fever group rickettsiae from ticks captured in Sudan. Morita, C., El Hussein, A.R., Matsuda, E., Abdel Gabbar, K.M., Muramatsu, Y., Abdel Rahman, M.B., Eleragi, A.M., Hassan, S.M., Chitambo, A.M., Ueno, H. Jpn. J. Infect. Dis. (2004) [Pubmed]

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